Chemotherapy was potentiated by E7449 and solitary agent had important antitumor action in BRCA-deficient xenografts. Moreover, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell strains, likely via TNKS inhibition. In line with this possibility, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and significantly altered expression of Wnt https://robertz974rva8.levitra-wiki.com/user