Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://ammona458wfk8.pennywiki.com/user