2. Histamine Receptor Antagonism: Some sedatives, including antihistamines, exert their sedative effects by blocking histamine receptors from the brain, specially H1 receptors. Histamine plays a task in wakefulness and arousal, so blocking its effects promotes sedation and sleepiness. With regards to the drug and whether it's Risk-free or not, https://wayloneasiz.free-blogz.com/80340237/sedative-medications-in-icu-their-roles-effects