Contraindicated (1)pentobarbital will lessen the extent or impact of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's active metabolites. pentobarbital will lessen the extent or effect of ibuprofen by affecting hepatic enzyme CYP2C9/ten metabolism. Minimal/Significance Unid... https://donovanypetj.activablog.com/33403261/new-step-by-step-map-for-pentobarbital-and-tablets-50